U.S. to Roll Out Groundbreaking HIV Prevention Drug Lenacapavir in Uganda

The United States has announced plans to introduce lenacapavir, a groundbreaking HIV prevention drug, in Uganda as part of its global fight against HIV/AIDS.

The development, unveiled by the U.S. Embassy in Kampala, marks Uganda as one of only ten high-burden countries set to benefit from the U.S. President’s Emergency Plan for AIDS Relief (PEPFAR). The initiative will support large-scale production and distribution of lenacapavir, with the potential to save hundreds of thousands of lives worldwide.

Lenacapavir, developed by U.S.-based Gilead Sciences, is administered just twice a year. Clinical trials show the medicine prevents HIV with over 99% effectiveness, offering a highly convenient and reliable option for people most at risk of infection. The drug is particularly significant for vulnerable groups, including pregnant and breastfeeding mothers.

Beginning in 2026, the United States will partner with the Ugandan Ministry of Health to roll out the new medication. Funding is being provided jointly by the U.S. government and the Global Fund, of which the U.S. is the largest donor, with plans to reach up to 2 million people across high-burden countries by 2028. Gilead has committed to providing lenacapavir at cost and has opened access to its intellectual property so that generic manufacturers can produce the drug affordably and sustainably.

U.S. Ambassador William W. Popp hailed the breakthrough as a testament to American scientific leadership and international cooperation.

“This medicine is an excellent example of how American leadership drives innovation to save lives. Collaboration between an American company and researchers right here in Uganda led to a medical breakthrough to reduce new HIV infections in the communities that need it most. This exciting development will accelerate our progress toward ending HIV as a public health threat, building a healthier future for America, Uganda, and the world,” Ambassador Popp said.

The Embassy confirmed that a detailed rollout plan will be developed in partnership with the Government of Uganda to ensure widespread and equitable access.